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- posted: Jun. 19, 2018
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Researchers pinpoint the neurons within white fat tissue that mediate brain-bound leptin signaling and eventual fat breakdown.
The hormone leptin, produced by fat cells, acts as a satiety signal to the brain, resulting in fat breakdown when levels are high. The hormone, present in proportion to the amount of fat tissue, is known to act on hypothalamic neurons in the brain to tell an animal when it’s full and to kick-start the breakdown of fat. Now, a team led by researchers at the Instituto Gulbenkian de Ciencia (IGC) in Portugal and the Rockefeller University in New York City have, for the first time, provided direct visual evidence that some sympathetic neurons from the brain indeed terminate within fat cells. The researchers also used optogenetics to stimulate these neurons within a fat pad in mice and cause the breakdown of fat. Their results were published today (September 24) in Cell.
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